Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (882)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (9) Inhibitors (540) Agonists (14) Antagonists (35) Activators (181) Modulators (30) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0252S2

Hydrochlorothiazide-¹³C₆		99.61%
Hydrochlorothiazide-¹³C₆ is the ¹³C labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.

HY-14256

BMS-191095	Activator	98.01%
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels.

HY-W027553

Ipidacrine	Inhibitor	99.81%
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K⁺ and Na⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.

HY-B0405S

Bupivacaine-d₉		99.04%
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain.

HY-18063

ML252	Inhibitor	99.9%
ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC₅₀s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC₅₀s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant .

HY-130353

Desethylamiodarone hydrochloride	Inhibitor	≥99.0%
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM.

HY-161104

Kv2.1-IN-1	Inhibitor	98.64%
Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC₅₀ of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K⁺, Na⁺, and Ca²⁺ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H₂O₂. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke.

HY-127106

VU0810464	Activator	99.33%
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC₅₀=165 nM) and GIRK1/4 (EC₅₀=720 nM) channels with improved brain penetration.

HY-N3463

Isopimaric acid	Activator	99.88%
Isopimaric acid is a potent opener of large conductance calcium activated K⁺ (BK) channels.

HY-B0407AS

Chlorpromazine-d₆ hydrochloride		99.88%
Chlorpromazine-d₆ (hydrochloride) is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, sodium channel.

HY-137563

A2793	Inhibitor	98.50%
A2793 is an efficient dual TWIK-related acid-sensitive K⁺ channel (TASK)-1/TRESK inhibitor, with an IC₅₀ of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1.

HY-N2338

Cholesterol myristate		≥98.0%
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

HY-135809

A2764 dihydrochloride	Inhibitor	99.05%
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K⁺ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC₅₀=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception.

HY-108589

PNU 37883 hydrochloride	Antagonist	99.66%
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, K_ATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells.

HY-108590

DMP-543	Inhibitor	99.96%
DMP-543 (XR-543) is a K_V7 channel blocker, also acts as a potent neurotransmitter release enhancer.

HY-108069

Iptakalim hydrochloride	Activator	≥98.0%
Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (K_ATP) opener, as well as an α₄β₂-containing nicotinic acetylcholine receptor (nAChR) antagonist.

HY-17451

Glibornuride	Inhibitor	98.92%
Glibornuride is a blocker of ATP-sensitive K⁺ channels (K_ATP channel) with a pK_i of 5.75. Antidiabetic agent.

HY-100276

Naminidil	Agonist	99.62%
Naminidil is a cyanoguanidine K_ATP opener.

HY-15209R

Repaglinide (Standard)	Antagonist
Repaglinide (Standard) is the analytical standard of Repaglinide. This product is intended for research and analytical applications. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

HY-W013175S2

Uridine 5'-monophosphate-¹³C₉,¹⁵N₂ disodium	Activator	≥99.0%
Uridine 5'-monophosphate-¹³C₉,¹⁵N₂ disodium is the ¹³C and ¹⁵N labeled Uridine 5'-monophosphate disodium salt (HY-W013175). Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

284compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (882)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (882):